#100 Cão, coração – Qual é o seu diagnóstico? ATUALIZADO 25/01/10
Photo by AFIP
Qual é o seu diagnóstico morfológico?
Coração, paraganglioma.
O paraganglioma foi confirmado por imuno-histoquímica: positividade citoplasmática difusa foi observada com os anticorpos anti-NSE e anti-cromogranina A. Paragangliomas são neoplasmas neuroendócrinos que se originam do tecido paragangliônico, que é um grupo de células neuroepiteliais do sistema nervoso autônomo. Essas células são da crista neural e são classificadas como cromafins (secretoras de catecolaminas) e não-cromafins (não-secretoras de catecolaminas).
Leia mais:
1. Fitzgerald PJ, Ports TA, Cheitlin MD, Magillian DJ, Tyrrell JB: Intracardiac pheochromocytoma with dual coronary blood supply: case report and literary review. Cardiovasc Surg 3: 557-561, 1995
2. Capen CC: Tumors of the Endocrine Glands. In: Tumors of Domestic Animals, ed. Meuten DJ, 4th ed., pp. 632–696. Iowa State Press, Ames, Iowa, 2002
3. Capen CC: The Endocrine Glands. In: Pathology of Domestic Animals, ed. Jubb KVF, Kennedy PC, Palmer N, 4th ed., pp. 345–347. Academic Press, San Diego, Ca, 1992
4. Becker AE: Tumors of the heart and pericardium. In: Diagnostic Histopathology of Tumors, Vol. 1, ed. Fletcher CDM, pp. 32–33. Churchill Livingstone, Hong Kong, 1996
5. Gidlewski J, Petrie JP: Pericardiocentesis and principles of echocardiographic imaging in the patient with cardiac neoplasia. Clin Techn Small Anim Prac 18:131– 134, 2003
6. Chan KMJ, Pontefract D, Andrews R, Naik SK: Paraganglioma of the left atrium. J Thoracic Cardiovasc Surg 122:1032-1033, 2001
7. Cane ME, Berrizbeitia LD, Sing SY, Mahapatro D, McGrath LB: Paraganglioma of the interatrial septum. Ann Thorac Surg, 61:1845-7, 1996
8. Turley AJ, Hunter S, Stewart MJ: A cardiac paraganglioma presenting with atypical chest pain. Eur J of Cardio-Thoracic Surg, 28:352-354, 2005
9. Brown IE, Milsshteyn M, Kleinman B, Bakhos M, Roizen MF, Jeevanandam V: Case 3-2002: Pheochromocytoma presenting as a right intra-atrial mass. J of Cardiothoracic and Vasc Anesth 16: 370–373, 2002
10. Okum EJ, Henry D, Kasirajan V, DeAnda A: Cardiac pheochromocytoma. J Thoracic Cardiovasc Surg 129:674-5, 2005
11. Tischer, AS: Paraganglia. In: Histology for Pathologists, ed. Sternberg SS, 2nd ed., pp. 1153-1172. Lippincott-Raven, Philadelphia, 1997
12. Burke A, Virmani R: Atlas of Tumor Pathology, Tumors of the Heart and Great Vessels, 3rd series, fascicle 16, pp.106-109. Armed Forces Institute of Pathology, Washington D.C., 1996
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Can I ask you something? What is the breed of this dog? I ask that because, as you know (extra adrenal nonchromaffin) paragangliomas of the heart (also called aortic body tumors and chemodectomas) have been seen more frequently in the brachiocephalic breeds of dogs (Bulldogs, Boxers, and Boston terriers). In these brachiocephalic dogs, the high frequency of chemodectomas may be caused by their partially obstructed air passages and by a genetic factor too (it has been suggested that the chronic hypoxia status associated with the upper respiratory tract anatomic conformation of these canine breeds would overstimulate the chemoreceptor organs causing hyperplasia and therefore an increased incidence of this neoplasia). Chemodectomas in man have familial predispositions too, and, similarly, it has been reported more often in people living in mountain areas. A good differential in this particular case that you posted would be ectopic thyroid tumors (like thyroid carcinomas for example) which can be located at the base of the heart of dogs too just like the one that is depicted in the image.
Olá Alex! O cão é um Rottweiler. desculpe-me pela demora pela resposta.
No problem! 8o) Thanks so much! :<)