#107 Esquilo cinza (Sciurus carolinensis), pele – Qual é o seu diagnóstico? ATUALIZADO 08/02/2010
Photo by Vet Pathol
Qual é o seu diagnóstico morfológico?
Pele, fibromatose (fibromas múltiplos)
Cutaneous and Systemic Poxviral Disease in Red (Tamiasciurus hudsonicus) and Gray (Sciurus carolinensis) Squirrels
D. S. BANGARI, M. A. MILLER, G. W. STEVENSON, H. L. THACKER, A. SHARMA, AND S. K. MITTAL
Abstract.
From September 2005 through October 2006, fibromatosis was diagnosed in 2 red squirrels (Tamiasciurus hudsonicus) and 1 gray squirrel (Sciurus carolinensis). All 3 squirrels had multifocal to coalescing, tan, firm alopecic cutaneous nodules. Two squirrels also had pulmonary nodules. Histologically, the cutaneous nodules had marked epidermal hyperplasia, with ballooning degeneration of keratinocytes, spongiosis, and eosinophilic cytoplasmic inclusions. The dermis was expanded by proliferation of atypical mesenchymal cells with cytoplasmic inclusions. Additional findings included pulmonary adenomatous hyperplasia with cytoplasmic inclusions, renal tubular epithelial hyperplasia with cytoplasmic inclusions, atypical mesenchymal proliferation in the liver, and atypical mesenchymal proliferation with cytoplasmic inclusions in the seminal vesicles. Ultrastructurally, poxviral particles were observed in skin scrapings and sections of cutaneous and pulmonary nodules. Polymerase chain reaction targeting the highly conserved Leporipoxvirus DNA polymerase gene was positive using DNA extracted from the cutaneous lesions of all 3 squirrels. Nucleotide sequence of the 390 base PCR amplicons was closely related to that of other members of the genus Leporipoxvirus. To the authors’ knowledge, this is the first report of cutaneous and systemic poxviral disease in American red squirrels with molecular characterization of the squirrel fibroma virus.
Key words: Gray squirrels; Leporipoxvirus; poxvirus; red squirrels; Sciurus carolinensis; squirrel fibromatosis; Tamiasciurus hudsonicus.
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Cutaneous fibromas by squirrel fibroma virus (genus Leporipoxvirus)?
Nice diagnosis. Would you call it nodular dermatitis?
Nope. To me this is a neoplastic condition, caused by an infectious agent (squirrel fibroma virus), and has been called leporipoxviral fibroma or squirrel fibromatosis. Typical light microscopic findings of this disorder include atypical mesenchymal fibroblast proliferation, epithelial hyperplasia with rete pegs projecting into the dense fibroblastic mass, epithelial ballooning degeneration, epithelial and mesenchymal eosinophilic intracytoplasmic inclusion bodies, and chronic-ative dermatitis formed by a mixed inflammatory cell infiltrate. The bulk of a cutaneous nodule like this one is formed by a densely cellular proliferation of spindle cells arranged in streams and bundles, separated by a moderate collagenous matrix, and that markedly expands the dermis, just like a fibroma is. I myself received/read a biopsy sample of such condition last year. Hope this helps.
I wouldn’t call it either.